Protein-glycosaminoglycan-protein Covalent Cross-link in Heavy Chain 2-Bikunin
نویسندگان
چکیده
منابع مشابه
Structural analysis of bikunin glycosaminoglycan.
The structure of an intact glycosaminoglycan (GAG) chain of the bikunin proteoglycan (PG) was analyzed using a combined top-down and bottom-up sequencing strategy. PGs are proteins with one or more linear, high-molecular weight, sulfated GAG polysaccharides O-linked to serine or threonine residues. GAGs are often responsible for the biological functions of PGs, and subtle variations in the GAG ...
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We present data that hyaluronan (HA) polysaccharides, about 14-86 monosaccharides in length, are capable of accepting only a single heavy chain (HC) from inter-α-inhibitor via transfer by tumor necrosis factor-stimulated gene 6 (TSG-6) and that this transfer is irreversible. We propose that either the sulfate groups (or the sulfation pattern) at the reducing end of the chondroitin sulfate (CS) ...
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ژورنال
عنوان ژورنال: Trends in Glycoscience and Glycotechnology
سال: 1993
ISSN: 0915-7352,1883-2113
DOI: 10.4052/tigg.5.401